Ammonia is toxic for various reasons:
1) In the ammonium ion form (NH4+), it disrupts Oxidative Phosphorylation by passing through the mitochondrial membrane and messing up the H+ balance.
2) If there is local production of Ammonia as NH3, with a PKa of around 9.3, it will disrupt the H+ balance of the body and hence physiological PH as well
3) It partakes in a redox reaction, hence it disrupts certain redox co-enzyme balances (i.e. NADH/NAD+ and NADPH/NADP+)
-Tosin A.O">">-----------------------------------------------------Ammonia is NEUROTOXIC; it inhibits the formation of neurotransmitters and inhibits the TCA cycle.While those three reasons listed may play a role, MEDICALLY speaking, the mechanism of ammonium neurotoxicity is unknown. Ammonia is extremely toxic to the brain, which is why our livers possess such a great potential for eliminating ammonia as urea. The current accepted hypothesis as to the effect of elevated blood ammonia is centered on glutamate/glutamine/alpha-ketoglutarate metabolism and the net result of inhibiting the synthesis of valuable neurotransmitters.
Increased ammonia results in alpha-ketoglutarate being converted to glutamate and in turn glutamine. The net result of this is twofold. First, there is decreased TCA cycle activity, as alpha-ketoglutarate is part of the TCA cycle, which means less ATP for the brain. Second, and perhaps more importantly, there are decreased levels of GABA and glutamate in the brain. GABA is a major inhibitory neurotransmitter, whereas glutamate is a major excitatory neurotransmitter. Both have many functions.
-A.D.Ammonia is ammonia and ammonia is toxic. Non-toxic ammonia does not exist. Ammonia can be diluted in water or held in a sealed container, but it's still toxic.
Ammonia is very toxic. So it has to be eliminated.
Yes
Yes ammonia can do that. It is toxic for rats.
no, ammonia is very toxic and is present in urine, if left to crystalize the reminance is ammonia salt.
Ammonia is approximately 3 times more toxic than urea in terms of acute toxicity. Urea is less toxic to aquatic organisms compared to ammonia because it undergoes nitrification in water, converting it to nitrate which is less toxic.
ammonia NH3
Urea is used in fertilizers and is not considered toxic. Ammonia is toxic and is what converts readily to urea.
No, you should not drink ammonia. Ammonia is a toxic substance that can cause serious harm if ingested, including damage to the throat, esophagus, and stomach. Ingesting ammonia can be life-threatening and should be avoided at all costs.
No they do not. Humans does not contain ammonia in urine.
Ammonia is typically more toxic than nitrate to aquatic organisms. Ammonia is highly toxic to fish even at low concentrations, while nitrate is less acutely toxic but can still be harmful at high levels, leading to issues like algae blooms. Both compounds can negatively impact water quality and aquatic ecosystems.
No. Ammonia is toxic. Even in small, nonhazardous concentrations the odor of ammonia is repulsive.