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In the 1760s, the largest port cities in terms of trade and commerce included London, which was a major hub for global trade, and Bristol, known for its significant role in the transatlantic slave trade. Other important port cities were Liverpool, which was rapidly growing as a center for shipping and trade, and Boston, a key entry point for goods in colonial America. These cities played crucial roles in the economic landscape of the time, facilitating the exchange of goods and ideas.

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