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A change in reference range refers to the adjustment of the normal values used to interpret laboratory test results, which can occur due to factors like population Demographics, health trends, or advancements in medical knowledge. Methodology changes involve alterations in the techniques or instruments used to perform tests, potentially affecting accuracy, sensitivity, or specificity. Together, these changes can influence clinical decision-making and patient management, as they may alter the interpretation of test results and the associated health implications.

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3mo ago

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