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Cystic Fibrosis
An inherited disease affecting exocrine glands and resulting in chronic infections in the respiratory system and faulty pancreatic function.
454 Questions
Is cystic fibrosis a dominant or co-dominant disorder?
It is autosomal recessive and it is not a disorder! Cystic Fibrosis is a disease.
Does Johnny Van Zant hane Cystic Fibrosis?
Ricky Medlock of Lynyrd Skynyrd on the Hannity Show on Fox News said in July 2009 that he had a mild case of cystic fibrosis and had part of (or whole) lung removed.
mild sprains or repeated injury could results in ganglion formation because of tearing of membrane covering the tendon
Would a person with Cystic Firosis be sterile?
Cystic Fibrosis can but not always lead to fertility problems. In most men with CF, the tubes that carry sperm are blocked, which causes infertility (approx 95%). Because underweight women are more likely to have irregular menstrual cycles, the nutritional problems associated with CF may affect fertility.
hope this helps
What organelle produces excess mucus in cystic fibrosis?
I believe this is the smooth ER. (Endoplasmic Recticulum). The smooth ER makes several types of lipids.
Is cystic fibrosis carried on a dominant of recessive gene?
Cystic fibrosis is an autosomal recessive genetic disease.
What is mecer infection for cystic fibrosis?
the only thing I can think of is MRSA or MERSA as doctors sometimes call it
What is a easy way to explain what Cystic Fibrosis?
Other than saying CF is a chronic illness there is no easy way to explain it. I have learned that once you say something it brings up more questions, I wrote a little pamphlet to try to get people to understand for fund raising time. All information gathered was from medical sites and professionals.
What is CF?
Cystic Fibrosis is the most fatal genetic disease in the US. There are approximately 70,000 people worldwide with the disease, and about 30,000 are in the US.
How do you get CF?
You can't catch CF. Cystic Fibrosis is a hereditary chronic illness. A person is born with the disease and to have it the person must have received a defective form of the autosomal recessive gene CFTR (cystic fibrosis transmembrane conductance regulator) from each parent.
Most people that have the defective gene don't know they have it, until they have a child that is born with CF. That is why awareness is so important.
When two people with the defective gene have a baby there is a 25% chance the child will be born with CF.
How does CF affect the body?
CF affects the body of every patient differently, but it targets all of the same areas.
The CFTR gene is responsible for producing the proteins our body needs to make mucus, sweat, saliva, tears and digestive enzymes properly. It is responsible for how chloride is transported through our bodies and helps control the movement of water in tissues and maintain the thinning of mucus and other secretions. It controls how sodium flows through our body. The functioning of these elements ensure that organs such as the lungs, pancreas, liver, and intestines work properly. When the gene is defective it causes abnormally thick mucus that is hard to break up. The blockage caused by the thick mucus causes lung infections, makes it to where our bodies can't absorb fat, causes serious digestive problems, clubbing of the fingers and toes, and progressive disability due to multisystem failure.
Since the way chloride and sodium isn't working properly, people with CF also sweat a lot and get over heated easily.
The imbalance of salt in the sweat can lead to heart problems, such as strain because of malnutrition and abnormal heart rhythms.
Infertility is also common with CFers and it affects both men and women. Statistics show that at least 97 percent of men with CF are infertile, and are missing the tube that connects the testes to the ejaculatory ducts of the penis, but are not sterile and can have children with assisted reproductive techniques. About 20% of women with CF are infertile. Others may have fertility issues due to thickened cervical mucus or malnutrition. In severe cases, malnutrition disrupts ovulation.
What are the symptoms?
Frequent infections, poor growth despite having a ravenous appetite, foul bulky stools or constant constipation, salty tasting skin, persistent coughing, and nasal polyps.
How are you diagnosed with CF?
CF can be diagnosed through newborn screenings, genetic and sweat tests.
What is the treatment for someone with CF?
Treatment varies on the patient. No two patients are the same.
No matter how well or poor each CFers health is they all have several medications, nebulized treatments and CPT (Chest Physical Therapy). This fills up a great portion of the day for them and their caregivers.
Will the medication get rid of CF?
No, there is not a cure for CF. It is a chronic illness and the condition of each patient deteriorates after time. That is why proper care, medication, further education and especially awareness is key to helping in the fight against CF.
How can I help?
There are many ways to help us in the fight. First and foremost is helping get the word out about the disease. This is the most fatal genetic disease there is in the US and the government doesn't help in supporting grants or research for better treatment for CFers. We want to get the word out that way we are closer to a cure. So with a simple forward to your friends by way of this application you can possibly help a pregnant woman get her child diagnosed early, before it's too late.
Second would be donations, every penny truly counts, and is 100% tax deductible. The Cystic Fibrosis Foundation is the main source for funding in the vital research, education, providing the necessary medication and supplying doctors who are dedicated to the fight and well being of those that have CF.
What happens to the body with cystic fibrosis?
It effects the body in a number of ways:
(1) Lungs- It is common for people with CF to encounter some difficulties with their lungs. But a combination of physiotherapy and medication can help control lung infections and prevent lung damage. To avoid the risk of cross infection, it is recommended that people with CF do not come into close contact with others with Cystic Fibrosis, which is why in so many hospitals people with CF are segregated.
(2) Digestive System- mucus blocks the digestive system making it hard for people with cystic fibrosis to digest food. This can be helped with the medicine "Creon" which is an enzyme which helps to break food down.
(3) Meconium ileus- In every ten babies born with CF, one is ill in the first few days of life with a bowel obstruction known as Meconium Ileus.
(4) Bones- due to the nutritional and other problems involved with the disease
(5) Infertility- Although people with CF are not deemed as 100% infertile, most men with Cf are due to blockages in the tubes that carry sperm, which causes infertility. Because underweight women are more likely to have irregular menstrual cycles, the nutritional problems associated with CF may affect fertility.
(6) Liver- Cystic Fibrosis can cause the blockage of small ducts in the liver. This only happens to approximately 8% of people who have CF, but it is a serious health risk and may necessitate a liver transplant
Cystic Fibrosis is a genetic lung disease. It makes the mucas in the body thick and sticky which can effect the entire body and can lead to an early death.
-edited to correct spelling :)
What happens if someone with cystic fibrosis releases few enzymes into there small intestines?
A peron realeses few enzymes into their small intestine. Explain what problem this causes
Can you carry the defective gene but not suffer from the disease cystic fibrosis?
Yes, because it is "autosomal recessive hereditary disorder".
Can you survive with cystic fibrosis and Down syndrome?
My daughter had Cystic Fibrosis and Down Syndrome. She died a little over a year ago at the age of 10.5 years.
What can cause ongoing pelvic pain when tests show no cysts etc?
Have you been to a Chiropractor? Poor pelvic alignment (torqued pelvis or tilted pelvis) can cause different kinds of lower abdominal, pelvic and lower back discomforts. I also was concerned that I had a cyst or something, but later found out my pelvis was torqued. This is fairly easy to correct if caught earlier than later. I required about a dozen adjustments before it started to hold it's position, because I waited almost a year before I thought to have my pelvic alignment checked. I now go in once every couple of weeks and since I've been holding well will now scale back to once a month checks. It might be worth looking into. Some Chiropractors offer a free first evaluation to determine your problem and what treatment you would need. I would take advantage of one of these, just to make sure.
Is cystic fibrosis linked to cerebral palsy?
No. Cystic fibrosis is a disease in the conduction and regulation of chloride ions across the intra cellular and extra cellular compartment. So in CF, there is an increase in the intracellular accumulation of chloride. This further deposited Chloride ions attract the Na ions since they are basically oppositely charged. And the Na ions are osmotic they tend to pull in the water molecule too. This causes drying of the normally secreting mucous leading to crusting of the mucus and obstruction to the lumen. So cystic fibrosis mainly affects the glands with hollow lumen! Like Bronchi, Pancreatic duct and Intestine [bowels]. So there is no way that CF could be linked to Cerebral Palsy which is more of neurological.
What kind of pattern of inheritance of cystic fibrosis?
Inheritance - Autosomal recessive, requires mutations on both alleles - A single gene on chromosome 7, which encodes for the cystic fibrosis transmembrane conductance regulator - There are over 1000 different mutations for this gene - The most common is Delta F508, which makes up 67% of all mutations in the Caucasian population - Caucasians most effected
Are there any other ways to get cystic fibrosis?
No, it is a hereditary disease meaning it's only in the family and oth parents have to hold the gene for the child to get CF, you have to be born with CF you can't get it like the flu. Say the mother was a carrier of the CF gene but the Dad is not, the child would only be a carrier, but if both parents are then it's likely the child will have CF
The pounding is manual chest physiotherapy (CPT). CPT, also known as pounds or clapping, uses manual poundingorpercussion to move mucus into upper airways where it can be coughed out. It is important to clear the lungs of as much mucus as possible in order to lessen the chance of infection and improve air entry into the lungs.
What type of mutation causes cystic fibrosis?
The most common mutation (seen in approx. 70% of cystic fibrosis patients) that causes the disease is known as Delta F508. It affects the functions of a gene found in chromosome 7 called Cystic Fibrosis Transmembrane Regulator (CFTR) by displacing it from its normal location on the chromosome. This prevents it from making a protein (which has the same name as the gene) responsible for ion channels used by Cl ions as well as Na ions. The former facilitates osmosis (diffusion of water). It also is known as an ATP-binding cassette transporter protein, which are able to span the biological membrane to transport a variety of materials, such as products of metabolism.
How are enzyme used as pharmaceutical supplements to treat cystic fibrosis disorder?
why are Enzymes are used as pharmaceutical supplements to treat cystic fibrosis disorder
What chromosome does cystic fibrosis effect?
The gene on chromosome 7 produces a protein called cystic fibrosis trans-membrane regulator. Mutation in the DNA level of chromosome 7 leads to the absence of this protein which leads to cystic fibrosis. Cystic fibrosis is a recessive disease.
