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When it's plugged in but not running (not sleeping, not hibernating), if you are careful enough there are no consequences. But it's highly recommended to unplug your computer while upgrading, cleaning and so on. If you insert the card while your computer is running it can easily fry the motherboard and power supply. All of what was said above is true if we are talking about PCI, -E, -X, and so on. If you are talking about USB, fireware, and so on. Then it's fine.

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15y ago

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