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The western Indian confederacy failed to limit white settlements west of the Appalachians primarily due to internal divisions among Native American tribes, which weakened their collective resistance. Additionally, the U.S. government's military power and policies, such as treaties that favored land cessions, further undermined their efforts. The relentless push of settlers, driven by economic opportunities and the ideology of Manifest Destiny, also played a significant role in overwhelming the confederacy's attempts to defend their territory.

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