Yes, however purist LEGO fans would not advise using the two together, as the colours do not match and purist Lego fans despise all other competing brands.
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Actually, Megablocks have longer interlocking parts, and unless you put the real Lego layer on the bottom, it won't work. I've tried it before. I'm not a purist, but I think sticking to one brand is probably better, just because they really don't work well together... not about the color, really, because color is a stylistic choice and you could make it work... but they don't interlock very well. I also think that Megablocks break more easily. Probably worth it because they are less expensive, but in case you are trying to decide between brands.
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