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The most effective Dominion game strategy to ensure victory is to focus on building a strong deck with a good balance of action cards, treasure cards, and victory point cards. Prioritize gaining cards that provide extra actions, buys, and card draw to increase your options each turn. Additionally, aim to thin your deck by trashing weaker cards and gaining powerful cards that synergize well together. Finally, keep an eye on the game state and adjust your strategy based on what your opponents are doing.

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