There are over 100 possibilities:
Puppy
Examples of 5 letter words with the second letter 'u' are:augerburntcurseduncedustyfudgefungifunnyguessguestguilthumanhumorjudgekudzulunchlurchmuralmusicnudgenurseoughtpunchqueenquellquestrummyrumorruralsuavesunnysushitulletumorwurstyuccayummy
quest...
slope
Fungi
Strait
Alter
braintrainframecreamdream
dummy
Some five letter words with the second letter A are:BaconbadgebanjoCadrecandyCanondancedaffydaisyeagerearlyearthfablefacetfaithgablegamuthabithairyhappyjauntkabobkayakkazoolabellancelaserMagmamatchmaybenachonastynaveloasispaperparchpartyrabidradioraisesaladsaltySatantabletainttalonvaletvalidvalvewaistwagonwateryachtyahooZaire
Some five letter words with the second letter U are:audioaugerbuglebunchcubiccurrydummydutchfudgeguanoguidehumidjudgekudzulucidlunchmusicnudgenuttyouterpulsepursequietquiltrustysupertuliptunicwurstyucca
Five letter words with second letter x are:excelexertextraaxiomexpel