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Washout in bioprocess engineering refers to the loss of microorganisms or cells from a bioreactor due to excessive dilution, often caused by high flow rates or inadequate retention mechanisms. This phenomenon can lead to reduced biomass concentration and diminished productivity, impacting the overall efficiency of the fermentation process. It is crucial to balance the inflow and outflow rates to maintain optimal conditions for microbial growth and metabolite production. Strategies such as using cell retention devices can help mitigate washout effects.

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2d ago

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