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A direct result of the conquest of Tenochtitlan by Hernán Cortés in 1521 was the collapse of the Aztec Empire, leading to significant Spanish control over Mexico. This conquest initiated a period of colonization, which resulted in the imposition of Spanish governance, culture, and religion on the indigenous populations. Additionally, it triggered widespread disease outbreaks, such as smallpox, which devastated native communities and further facilitated Spanish dominance. The event also marked the beginning of extensive European colonization in the Americas.

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