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Gold seekers crossed the Isthmus of Panama primarily through a challenging overland trek, often via the Panama Trail, which connected the Caribbean Sea to the Pacific Ocean. Many traveled on foot or on horseback, facing harsh terrain, tropical diseases, and the threat of bandits. Some opted for a quicker but more expensive route, using boats to navigate the Chagres River. This journey was part of the larger Gold Rush era, particularly during the California Gold Rush in the mid-19th century.

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