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Take the Uptown 1-2-3 (the red line), from 34th Street-Penn Station to 42nd Street-Times Square. Transfer at Times Square to the S shuttle train (color grey), or the Uptown 7 train (the purple line) if the shuttle isn't running. Take the S or 7 to 42nd Street-Grand Central (at Park/Lexington Avenues).

Then walk 1.5 blocks north on Lexington Avenue to 420 Lexington, between 43rd and 44th Streets.

Or, you can just walk. Penn Station is at 33rd to 34th Streets, between 8th and 7th Avenues. Walk north on 8th or 7th Avenues to 42nd Street, turn right, and walk east on 42nd Street to Lexington Avenue. Then walk 1.5 blocks north on Lexington to 420 Lexington. It's a 1.25 mile walk from 8th Avenue, and slightly less than that from 7th Avenue.

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