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The fall of Constantinople in 1453, which marked the end of Byzantine control and the rise of the Ottoman Empire, disrupted traditional land trade routes to Asia. European powers, particularly Portugal and Spain, sought new maritime routes to access Asian spices and goods, leading to increased exploration. This quest ultimately resulted in Christopher Columbus's 1492 voyage, which unintentionally discovered the New World, as Europeans sought alternative pathways to the lucrative markets of Asia.

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