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Conflicts between the pope in Rome and the patriarch in Constantinople primarily led to the Great Schism of 1054, resulting in the formal division between the Roman Catholic and Eastern Orthodox Churches. This schism caused theological, political, and cultural rifts, diminishing the unity of Christianity in Europe and the Mediterranean. The disputes over authority, doctrine, and practices fostered regional identities and influenced the development of distinct ecclesiastical traditions, contributing to long-lasting tensions between Western and Eastern Christian communities. Furthermore, these conflicts set the stage for future religious and political confrontations, including the Crusades.

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