What is the Best driving route from Harrisburg PA to San Diego CA?

Answer 1

1. Take I-81 SOUTH to I-40 WEST to KNOXVILLE at EXIT 1B in Tennessee.
2. Take I-40 WEST to I-75 SOUTH to CHATTANOOGA at EXIT 368. On this stretch you will bypass Knoxville by taking I-640 WEST (EXIT 393 off I-40).
3. Continue on I-75 SOUTH to I-24 WEST to CHATTANOOGA and BIRMINGHAM at EXIT 2.
4. Take I-24 WEST to I-59 SOUTH to BIRMINGHAM at EXIT 167.
5. Take I-59 SOUTH to I-20 WEST to JACKSON at EXIT 149 in Mississippi. In Alabama, you will bypass Birmingham by taking I-459 (EXIT 137 off I-59).
6. Continue on I-20 WEST all the way across Mississippi and Texas to I-10 WEST to EL PASO at where I-20 ENDS in western Texas. In Louisiana you will bypass Shreveport by taking I-220 WEST (EXIT 26 off I-20 then EXIT 1B off I-220 to get back onto I-20 WEST.
7. Take I-10 WEST across Texas and New Mexico to I-8 WEST to San Diego at EXIT 199 in Arizona. This will be well past Tucson.
8. Take I-8 WEST to San Diego.