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The best driving route from Knoxville, TN, to Jackson, MS, typically involves taking I-40 West to I-55 South. This route will take you through Memphis, providing an opportunity to enjoy the sights of the city before continuing south. The total distance is approximately 380 miles and usually takes around 5.5 to 6 hours, depending on traffic conditions. Always check for real-time updates on road conditions to ensure a smooth journey.

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2mo ago

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