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About 332 miles on the southern route. About 344 if one travels through Nashville using the interstate highways.
340 miles taking this route:

  1. Take I-40 EAST, from Memphis, to I-440 EAST to KNOXVILLE off EXIT 206.
  2. Take I-440 EAST, around DOWNTOWN Nashville, to I-24 EAST to CHATTANOOGA.
  3. Take I-24 EAST to Chattanooga.

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