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The Miami-Mexico City or Orlando-Mexico City air routes, which fly over the Gulf of Mexico.

Otherwise, you would have to take the Interstate 10 (I-10) all the way to San Antonio, TX. From there, take the Interstate 35 (I-35) to the south, arriving to Laredo, TX. When on Laredo, you can cross the border to Nuevo Laredo city, on the Mexican state of Tamaulipas.

The reverse is also true.

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