What is the shortest route by road from Philadelphia to Buffalo?

Answer 1

1. Take I-476 (Northeast Ext of Pennsylvania Turnpike) (toll) NORTH to I-81 towards BINGHAMTON and WILKES-BARRE. You want I-81 NORTH towards BINGHAMTON.
2. Take I-81 NORTH through Pennsylvania to I-90 New York State Thruway (toll) towards ALBANY and BUFFALO at EXIT 25A just north of downtown Syracuse. You want I-90 WEST towards Buffalo.
3. Take I-90 WEST along the New York State Thruway to Buffalo.

Answer 2

Kayaking on the Erie Canal to the Hudson to NYC.

Answer 3

Just take the thruway EAST on I-90 and, eventually, SOUTH on I-87 to New York.

Answer 4

bus or car