130-0 vs Michigan on October 22, 1904.
Wisconsin
1996 they lost to Ohio State 72-0.
Any loss to Iowa State is arguably the worst loss ever.
The loss of dignity and innocence for the whole program in 2011. Or the 79 Sugar Bowl.
James Madison
Missouri's worst loss in football occurred on October 31, 1975, when they were defeated by the University of Kansas with a score of 55-0. This game marked a significant low point for the program, as it was a humiliating defeat against their longstanding rival. The loss is often remembered as one of the most lopsided games in Missouri's football history.
67-28-5 UofM
There worst lost was against the timberwolves
The worst loss for the Ohio State Buckeyes football team at Ohio Stadium occurred on November 18, 1995, when they were defeated by the Michigan Wolverines with a score of 31-0. This shutout marked a significant low point for the Buckeyes, as it was one of the most lopsided defeats in the storied rivalry between the two teams. The loss not only impacted their season but also left a lasting mark in the history of their home games.
The Oklahoma City Bombing.
The Wolverines lead 67-29-5