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The Montreal Protocol, signed in 1987, was primarily driven by health concerns related to the depletion of the ozone layer, which allowed increased UV radiation to reach the Earth's surface. This rise in UV exposure was linked to higher rates of skin cancer, cataracts, and other health issues. Additionally, the protocol aimed to address the harmful effects of ozone-depleting substances on respiratory health and overall public well-being, prompting global action to protect both human health and the environment.

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