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The founding of Maryland and Pennsylvania was significantly influenced by regional religious and political tensions in 17th-century England. Maryland, established by Lord Baltimore in 1632, served as a refuge for Catholics facing persecution, while Pennsylvania, founded by William Penn in 1681, was a haven for Quakers seeking religious freedom. The geographic location of both colonies, near the Chesapeake Bay and the Delaware River respectively, facilitated trade and settlement, attracting diverse populations. This regional emphasis on tolerance and agriculture shaped their social and economic development.

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