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Grand Central Station is on 42nd Street, between Park and Lexington Avenues. Take either the Uptown A-C-E* (the blue line) or the Uptown 1-2-3 (the red line), one stop, from Penn Station (West 34th Street) to Times Square (West 42nd Street).

At the Times Square Station, transfer to the S shuttle train (color code grey), east across 42nd Street, from Times Square (West 42nd) to Grand Central (East 42nd).

*Note that the 42nd Street stop on the A-C-E is actually not Times Square. Since the A-C-E runs up and down 8th Avenue, while the Times Square Station is at 7th Avenue, the 42nd Street stop on the A-C-E is actually 42nd Street-Port Authority Bus Terminal. BUT, there is an underground tunnel connecting the A-C-E to the Times Square Station, so you can transfer without exiting the subway system.

So, it is preferable to take the Uptown 1-2-3 from Penn Station to Times Square, rather than the Uptown A-C-E, to save yourself the walk through the tunnel. But if you can't find the 1-2-3, or if the A-C-E happens to be right there when you get off your train at Penn Station, you can take it.

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