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One significant factor keeping Europeans out of interior Africa until the late 19th century was the challenging geography and climate, including dense forests, swamps, and disease-ridden areas, particularly the prevalence of malaria and yellow fever. Additionally, the lack of navigable rivers and the presence of powerful local kingdoms made exploration and colonization difficult. These obstacles, combined with limited knowledge of the continent's interior, delayed European penetration until advancements in medicine and technology facilitated exploration.

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