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The Missouri Compromise, enacted in 1820, admitted Missouri as a slave state and Maine as a free state to maintain the balance between slave and free states in the Senate. It also established a line (the latitude of 36°30') north of which slavery was prohibited in the Louisiana Territory, except for Missouri. This compromise temporarily eased tensions between the North and South over the issue of slavery but ultimately highlighted and intensified the sectional conflicts that would lead to the Civil War.

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