Inasmuch as "contagious disease" can be counted as a natural process, smallpox (and to a lesser extent, measles) killed off millions of Aztecs and Incas. It has however been suggested by recent research that instead of smallpox imported from Europe, an indigenous - and until then, mostly dormant - form may have been responsible: a number of the symptoms described by people at the time do not match those of the "European" smallpox.
Disease
Spanish colonization of the Americas ended in 1821.
Spanish colonization of the Americas was created in 1525.
Both Britain and France challenged Spanish power in the Americas.
Gold was known to exist in the Americas.
In 1492, with the arrival of Columbus in the Americas.
The spanish
Horses
major and largest empire in the Americas
They were brought to the Americas for slavery.
yes
King Ferdinand of Spain granted encomienda to the Spanish settlers in the Americas.