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Most sixteenth-century seafaring expeditions sailed south of what is now the east coast of the United States primarily to find a more favorable route to the riches of Asia, including spices and silks. The warm Gulf Stream current and prevailing winds facilitated navigation along the Atlantic, while the southern route offered opportunities for exploration and colonization in the Caribbean and parts of Central and South America. Additionally, explorers were often driven by the desire to claim new territories for European powers, leading them to focus on regions like Florida and the Gulf of Mexico.

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