The best route to drive from Chicago to Pittsburgh is to take Interstate 90 East to Interstate 80 East. This route is the most direct and efficient way to reach Pittsburgh from Chicago by car.
The easiest would be to get on Interstate 80 at Chicago and follow it all the way to northern California.
The exit that would be half way from Iowa city to Chicago il on interstate 80 is the Great White Way.
You take I-80 for about 80 miles.
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About three to four hours on 80/90 through Ohio, Indiana, and Illinois. If you are in Michigan and don't hit rush hour in Gary and Chicago, count on a good four hours on I94 and then 80/90.
Depending on traffic, the actual departure point and actual destination point within Cincinnati and Chicago, and depending on traffic conditions through Indianapolis, anywhere between 4½ and 5½ hours via Interstate 74 to Interstate 465 to Interstate 65 to Interstate 80/94 to Interstate 94 Chicago Loop.
Iowa City is 228 miles directly west of Chicago on Interstate 80.
Interstate 80 across to San Francisco. Interstate 80 to Interstate 15, then 15 to LA, or alternately, work down to I 70, then 15 to LA.
Take I-80 EAST to Chicago.
It is 790 miles via Interstate-80 according to Google Maps.
Interstate 80 and Interstate 25.