What is the best driving route from Miami to Jefferson City?

Answer 1

1. Take I-95 NORTH to Florida's Turnpike (toll road) at EXIT 12A (LEFT EXIT).
2. Take Florida's Turnpike (toll) NORTH to I-75 NORTH north of Orlando.
3. Take I-75 NORTH through Florida and Georgia to I-24 WEST to CHATTANOOGA and Nashville at EXIT 2 in Tennessee. On this stretch, bypass Macon, Georgia by taking I-475 NORTH (EXIT 156) and bypass Atlanta, Georgia by taking I-285 WEST BYPASS (EXIT 238B off I-75 and then EXIT 20 off I-285 to get back onto I-75 NORTH).
4. Take I-24 WEST through Tennessee and Kentucky to I-57 NORTH to CHICAGO at EXIT 44B in Illinois.
5. Take I-57 NORTH to I-64 WEST to St. Louis at EXIT 96.
6. Continue WEST on I-64 to I-255 to CHICAGO and MEMPHIS at EXIT 7 outside of St. Louis in nearby Illinois.
7. Follow signs to I-255 NORTH to CHICAGO. Take I-255 NORTH to I-270 to INDIANAPOLIS and KANSAS CITY at EXIT 30.
8. Follow signs to I-270 WEST to KANSAS CITY. Take I-270 WEST into Missouri where you will exit at EXIT 20B onto I-70 WEST to KANSAS CITY.
9. Take I-70 WEST to US-63 to JEFFERSON CITY and MOBLERLY at EXIT 128A.
10. Follow signs to US-63 SOUTH to JEFFERSON CITY. Take US-63 SOUTH to Jefferson City.