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The best route from Wilmington, NC, to Naples, FL, typically involves taking I-40 W to I-95 S, then merging onto I-75 S towards Naples. This route covers approximately 600 miles and usually takes around 10-11 hours, depending on traffic and road conditions. For a scenic alternative, consider taking US-17 S along the coast before connecting to I-75. Always check for real-time traffic updates before starting your journey.

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1mo ago

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