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Yes- Ronald Reagan challenged Ford for the nomination in 1976 .

Ted Kennedy challenged Carter in 1980.

Bobby Kennedy ran against Lyndon Johnson in 1968 and did so well that Johnson dropped out.

In 1912, ex-President Roosevelt failed to take the Republican nomination from incumbent President Taft , so he formed his own party and ran against him for president.

President Fillmore actually lost the Whig nomination to Winfield Scott in 1852 . President Pierce lost the nomination to James Buchanan in 1856.

President Arthur lost the republican nomination to James Blaine in 1884.

President Andrew Johnson, who had been elected as a Republican, tried for the Democratic nomination in 1868, but lost.

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