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Two former Secretaries of State Henry Clay and James G. Blaine ran for president and lost. Two others, Lewis Cass and William Jennings Bryan served as Secretary if State after losing a national run for the White House. Daniel Webster made a bid for the presidential nomination after serving as Secretary of State , later served again as state secretary and later tried again to be nominated.

William Seward, Edmund Muskie, Alexander Haig and Hilliary Clinton served as Secretary of State after losing a run for their party;s presidential nomination.

(Former Secretaries of State Jefferson, Madison, Monroe, John Q. Adams, VanBuren, and Buchanan all won the presidency .)

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