That depends on your definition of significant, if that means causing a change in politics then yes. The AIM (American Indian Movement) and other Native American groups, took several actions that caused world wide media attention, and several (false) political promises by US Government leaders:
These are only a few of the great many conflicts that you never hear about anymore. Information contained in this answer is derived from several sources, including: The American Indian Occupation of Alcatraz Island, Troy R. Johnson ISBN:978-0-90
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yes its main target is the injustises of the US government towards these people the only difference is uncle tom's cabin is a narrative story, Bury My Heart At Wounded Knee is a history
The Omaha tribe was the Native American group that had trading villages on the Missouri River. These trading villages were greatly affected by a smallpox epidemic, killing a significant proportion of their populations.
The radical Native American group that called for Native American lands to be returned is the American Indian Movement.
A painting depicting native American land.
there is no such word in the native American vocabulary.