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The Midwest region of the United States has witnessed numerous significant historical events, including the westward expansion during the 19th century, exemplified by the Oregon Trail and the California Gold Rush. The region played a crucial role in the Civil War, with states like Illinois and Ohio being key Union supporters. Additionally, the Midwest was central to the Industrial Revolution, transforming cities such as Chicago and Detroit into major industrial hubs. The Great Migration in the 20th century also saw a large movement of African Americans from the South to the Midwest, significantly impacting the cultural landscape.

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