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Barbara Bush faced several challenges throughout her life, including the pressures of being in the public eye as First Lady, where she had to balance her family life with her role in politics. She also dealt with personal struggles such as the loss of her daughter Robin to leukemia at a young age, which profoundly impacted her. Additionally, she confronted the challenges of advocating for literacy and education in a polarized political climate, often promoting initiatives that required bipartisan support. Throughout these experiences, she maintained a commitment to her family and her philanthropic work.

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