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Monoclonal antibodies are typically designed to target a single antigenic determinant, which allows for high specificity in binding to that particular epitope. However, some monoclonal antibodies can exhibit cross-reactivity, recognizing multiple related epitopes or antigens due to structural similarities. This can be advantageous in certain therapeutic or diagnostic contexts but may also lead to unintended interactions. Overall, while monoclonal antibodies are primarily specific, their reactivity can occasionally extend to several antigenic determinants.
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Why polyclonal antibody tend to have cross-reaction compare to monoclonal antibody?
Polyclonal antibody recognizes several epitopes on the target protein while monoclonal antibody recognizes only single epitope, hence monoclonal antibodies are more specific than polyclonal antibodies. However, sometimes MAbs are not able to precipitate the antigen because the epitope might need to be exposed on the surface of the antigen to be recognized by the antibody. Since some of the epitope might be hidden and it's a single epitope that is recognized by the monoclonal antibody, the propability of the antibody to reconize the epitope is lower compared with the polyclonal antibody that recognizes several epitopes on the target protein this is the reason for the tendency of polyclonal antibodies to have cross-reaction as compared to MAbs. by Victor S Gruezo Jr
Why polyclonal antibody solution is able to precipitate its antigen protein whereas monlclonal antibody solution has hard time to do so?
Polyclonal antibody recognizes several epitopes on the target protein while monoclonal antibody recognizes only single epitope. Sometimes, monoclonal antibodies are not able to precipitate the antigen because the epitope might need to be exposed on the surface of the antigen to be recognized by the antibody. Since the epitope might be hidden and it's a single epitope that is recognized by the monoclonal antibody, the propability of the antibody to reconize the epitope is lower compared with the polyclonal antibody that recognizes several epitopes on the target protein.
Construction and fermentation of Antibody drug?
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope. Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see "Nomenclature of monoclonal antibodies"), and many immunotherapy specialists use the word mab anacronymically.
What are the determinants of investment?
1. Revenue: Economic Growth and Business Cycle 2. Cost: Interest rates and Taxes 3. Expectation: Stable economic and political condition of any country.
What determine an enzymes activity?
There are several things that determine an enzyme's activity. The main determinants include the structure of the enzyme, temperature, pH and so much more.
What do you learn in university mathematics course?
Math of course! OK, seriously, there are several topics which you learn; what topics you take, and to what level you learn math, depends a lot on the career you choose, and the specific university. Some typical topics include calculus (differentiation, integration, differential equations, etc.), matrixes and determinants, statistics, probability, and many others.
How many feet are in several miles?
Several is not a specific amount. It is more than two, but not many and so it does not have a specific value. So there is no specific answer to your question.
Who played Cleopatra's son?
There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.There were several child actors who played Cleopatra's son in the several Cleopatra movies. You would have to be more specific about the movie for your question to be answered correctly.
Use specific in a sentence?
I can give you several sentences.Give me a specific example of that word.I am looking for one specific animal in that herd.This is a specific case.
Does infliximab work for other skin conditions other than psoriasis?
Yes, infliximab, a monoclonal antibody that targets tumor necrosis factor-alpha (TNF-alpha), is effective for several other skin conditions beyond psoriasis. It is commonly used to treat conditions such as hidradenitis suppurativa and certain types of dermatitis, including atopic dermatitis. Its anti-inflammatory properties make it beneficial for various autoimmune skin disorders. Always consult a healthcare provider for specific treatment recommendations.
What are the determinants of money multiplier?
The money multiplier is influenced by several key determinants, primarily the reserve requirement ratio set by the central bank, which dictates the fraction of deposits that banks must hold in reserve. Additionally, the willingness of banks to lend and the public's preference for holding cash versus deposits affect the multiplier; higher demand for cash reduces the multiplier. Finally, the overall health of the economy and confidence in the banking system can impact lending practices and deposit behaviors, further influencing the money multiplier.
Who is in the US army?
There are SEVERAL Generals. Did you have a specific one in mind?
