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Isaac defeats the Hive Mind and blasts off in an escape shuttle moments before a huge chunk of Aegis impacts the planet. As Isaac drifts away in space, he removes his helmet and watches some of the video from Nicole before turning off the ship's holographs entirely.

As he lay back, he notices something move in his peripheral vision. He turns and is suddenly attacked by a necromorphed Nicole. The credits roll and Isaac's fate is yet to be determined in Dead Space 2.

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