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Maybe the worst is numbness of the thumbs or itchy eyes that's about it i think.

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He is right but i also think if your playing all night or so, you begin to get a horrible headache. and your thumbs don't necessarily get numb, but at a certain point they will feel a little funny and/or kind of cramp. your eyes will also burn more than Itch. But sometimes they will do both. If you do overcome any other pain, just Google it and make sure its normal.

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7y ago

What else can I help you with?