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You may hurt more than the barrel. The .22 magnum is a larger diameter CASE and BULLET than the .22 LR (22 is a name, not a measurement). When a LR cartridge is fired in a Magnum chamber, there is a high chance the casing will split, possibly blowing bits of metal and hot gasses out of the chamber. There ARE revolvers made that will shoot both- but they use different cylinders. Do not try this- it is dangerous.

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