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No. The .22 is smaller in diameter than the .25 and would be too small for the chamber of a .25. Generally speaking, you should never try to fire any cartridge in any handgun other than what it is designed to fire. While it may be possible to get a cartridge to fire from a different gun, it may cause damage to the gun or the shooter. Additionally, I forgot to mention that the .22 is a rimfire cartridge and the .25 is a center fire, the the firing mechanism is slightly different in the two guns.
What else can I help you with?
If i have a handgun that says 22 long rifle what kind of bullets does it take?
.22 Long Rifle bullets...
Can a 22 cal air gun shoot 22 cal bullets?
No
Can you shoot .22 Win Mag bullets out of a .22 single shot bolt action?
No. .22mag. bullets are too long, and they aren't heel-type bullets
Can a 22cal airgun shoot 22cal bullets?
No it can only fire 22 caliber pellets not bullets.
What bullets does fie 22 revolver shoot?
Probabably 22LR. Have it checked by a gunsmith.
Does a JStevens 32 long rifle shoot 22 long bullets?
NO NO NO! Only shoot what the rifle is chambered for and so marked.
Can you shoot hollow point 22 LR bullets in a 22LR Henry lever action?
Yes
What grain bullets can be shot out of a Davis industries model dm-22 cal 22 mag two shot handgun?
Whatever is available ought to be OK. (40grains.....)
What kind of bullets does a m49 Ithaca lever action single shot 22 caliber rifle shoot?
22 Long Rifle
What handgun holds the most bullets?
Lakeside Razorback belt-fed .22 long rifle pistol, 200 round capacity belts.
Can a marlin model 80 s-l-lr shoot 22 magnums?
No! The .22 magnum is different dimensionally. Do not attempt to chamber a .22 Magnum in a rifle or handgun designated for .22 s,l or lr. In most cases the barrel of a rifle or handgun will indicate the chambering!
What bullets does a 22 revolver take?
A .22 revolver takes CARTRIDGES. Which .22 cartridge will depend on what caliber the revolver was made for. A .22 LR can shoot Long Rifle or Short cartridges, and a .22 WMR uses .22 magnum cartridges. They do not interchange. There are a few .22 revolvers that have 2 cylinders, and can shoot either cartridge.
