For the most part, Spanish and Portuguese conquerors landed on, or marched into what is now the continent of South America. Yes the Spanish Conquistador Cortes first conquered the Aztec Indians in what is now called Mexico. There is now of course only 2 continents in the Western Hemisphere. North America & South America. South America begins at the southern most part of Panama. For ease of identification, the term Central America is often used to describe the area of Mexico and Panama. This however, is not true geography.
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Juan Ponce de león
he was a naturalist that explored south America and was the first to say that Africa and South America were once one continent.
The first Europeans to come to the mainland of the United States were likely the Vikings about 1000 AD. However, Hernando De Soto was the first Spanish explorer to explore part of what became the United States in 1516.
Puritans when they landed in 1620 in Mass and set up Plymouth colony. The first European religion to be brought to the Americas with lasting effect was Christianity, and specifically Roman Catholicism, in the Caribbean, Mexico and South America, beginning with Columbus' expedition of 1492. Various Protestant sects also established early presence in the English Colonies starting with the settlement of Virginia in 1609.
If you mean landed on. It was the moon in 1969 and the man who landed there was Neil Armstrong for the United States.