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The KK-Aymouse a type 2 diabetic model that exhibits marked obesity, glucose intolerance, severe insulin resistance, dyslipidemia, and hypertension. KK-Aymice also develop renal disease characterized by moderate albuminuria with mild glomerular pathology and podocyte loss. Male mice exhibit hydronephrosis, a form of renal obstruction, while females do not.

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11y ago

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