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Most, if not all, organisms can produce glucose. Humans and other animals can produce glucose when necessary from other carbohydrates and intermediates (such as glycogen, lactate and pyruvate). This requires, at some point, consumption of autotrophs, to provide the energy and carbon required to produce glucose.

Autotrophs can produce glucose (directly or indirectly) from inorganic molecules (i.e., not from eating other organisms).

Photosynthetic organisms (photoautotrophs) are autotrophs that specifically produce glucose from light energy. This includes plants, algae and some bacteria (e.g. cyanobacteria).

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