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The first animal to go to the International Space Station (ISS) was a Russian tortoise named "Tortoise." It was launched aboard the Soviet Union's Zond 5 spacecraft in 1968, before the ISS was constructed. However, in the context of the ISS specifically, mice were among the first animals sent there to study the effects of microgravity on living organisms. The ISS has since hosted various animals for scientific research, including fish, frogs, and fruit flies.

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