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For clarity, let us consider the systems before we address this question.

The lymphatic system filters the fluids that bathe cells in the body, trapping bacteria and viruses in lymph nodes. From here immune responses can be mounted to clear the invading matter. A part of the nervous system, referred to as the sympathetic nervous system, does indeed connect with these lymph nodes. This particular arm of the nervous system normally prepares the body to better cope in situations of stress (fight, flight, fright response). So this implies that the immune system may be shunted into a higher level of function in times of acute stress. It also might explain why chronic stress has the opposite effect via desensitization, meaning a greater change of infection.

Now, since the connection is via the peripheral nervous system, and the role is modulatory, it follows that CNS damage - assuming it is non-fatal and does not result in profound loss of function - would not lead to 'malfunction' in the lymphatic system. But it could lead to acute of chronic changes in immune responsiveness, depending on sympathetic activation.
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Q: Can central nervous system damage lead to malfunction in the lymphatic system?
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