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Depo Provera may affect both vaginal discharge and mood. Talk with your heatlh care provider to determine if your change in discharge needs evaluation for possible infection, and talk about options for changing methods if the mood changes are a problem for you. You may find that the mood changes resolve within a few weeks after the first injection, or they may persist.

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9y ago
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12y ago

In my experience & many others, heck yes! Within days of getting my 1st shot I was a complete mess & my emotions went from crying to screaming mad in a matter of minutes sometimes, it was like being possessed! & u cant do anything about it till it wears off. I haven't noticed any weight gain (another common side effect) just yet although i have been having crazy dreams every night since but the Depo definitely screwed with my mental state, I just wasn't me all off a sudden & this craziness just kept sneakin up on me without warning & I couldn't control my emotions. After doing some research I found that a lot of women have no problems & I am glad that it works for them but for me & alot of other women I have no doubt it ruined my life. Don't touch it if u have any history of depression or hormonal imbalance! I have 2weeks left until my 3mths is up & am just starting to feel normal again, will never touch it again.

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10y ago

I have been off of the Depo shot for 3 months now and I have lately been extremely depressed. The only thing that keeps me stable is excercise. I've been searching the net all over trying to find the same answer to this question

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11y ago

I would say yes, even though I've only been on the shot for almost 3 weeks I have been crying more, getting angry more, and i believe i exploded at my boyfriend for the first time even though we've been together for a long time and never had a fight. So i stand by yes it makes you emotional.

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Talk to your doctor. Sometimes, side effects can be mitigated by other drugs.

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Q: Can Depo-Provera cause discharge and moodiness?
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