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You can, however it is not recommended. Pristiq is an inhibitor and prevents the Buprenorphine (active ingredient in Suboxone) from working as well as it should. Buprenorphine is broken down in the liver and the inhibiting action of Pristiq prevents the liver from doing its job in breaking Buprenorphine down. This is referred to as a "Side by Side Effect" of taking the two drugs at the same time. It's sad to say, but a lot of Buprenorphine Certified Physicians are completely unaware of this. Pristiq is not the only drug that will do this. Others include (but not limited to) Prozac, Paxil, Zoloft, Luvox, Lexapro & Celexa are all SSRIs, and Pristiq is an SNRI as is Cymbalta. You should discuss your Suboxone and Pristiq treatment with a qualified physician that is knowledgeable in the pharmacology and side by side effects of these two drugs to determine if the benefits outweigh the disadvantages of taking these two drugs at the same time.

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13y ago
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14y ago

Ambien is a hypnotic CNS depressant and pristiq is an anti-depressant. While they can be taken together, watch for signs of worsening depression.

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Q: Can you take suboxone and pristiq at the same time?
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