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Tramadol is a synthetic opioid analgesic, it is not an opiate. Tramadol is a fairly weak opioid which also has pharmacological actions like a serotonin norepinephrine reuptake inhibitor, a type of antidepressant like Effexor (venlafaxine). Tramadol has been shown to be particularly effective in treating neuropathic pain in part do to its effects on serotonin and norepinephrine. Most of tramadol's opioid actions are to its active metabolite O-desmethyltramadol, an opioid hundreds of times more potent than tramadol itself.

Some people find tramadol to have stimulating effects as a result of its actions on serotonin and norepinephrine.

Klonopin (clonazepam) also known as Rivotril outside of The United States is a benzodiazepine used as an anticonvulsant and for panic disorder. However it is commonly used off label to treat other anxiety disorders, as a muscle relaxant, and for neuropathic pain. Unlike opioids which are not technically "depressants," Klonopin is a central nervous system depressant acting on GABA, the principal inhibitory neurotransmitter. Klonopin is routinely combined with opioids to boost the effect of opioids (thus requiring a lower dose of opioids), to help with any muscle problems, and Klonopin can help alter pain signaling. Klonopin reduces the ability for nerves to fire which is why it can help anxiety and epilepsy and since there are fewer nerves firing there is somewhat less transmission of pain signals.

As long as you take your medications as prescribed you should be fine.

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14y ago
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14y ago

I looked it up and don't see any interactions. But that does not mean there aren't any. Call your pharmacist he/she will be able to provide you with a better answer

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14y ago

yes

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11y ago

yes

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11y ago

yes

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