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How long will it take to drive from Miami to Key West Florida?

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It is 154 miles to Miami. It will take 3.5 hrs without traffic.

MapQuest estiimates the driving time as 3 hours and 33 minutes.
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How long does it take to drive from Orlando Florida to Miami Florida?

MapQuest gives the estimated driving time as 3 hours and 41 minutes. ^^^ To improve on this you can definately get from Orlando to Miami in around 3 hours if you do the follow

How long does it take to drive from Miami airport to key west?

  About 3.5 hours - maybe 4 depending on road construction. The hardest part is getting out of Miami to Key Largo - then it's a 2 lane highway through all the keys to Key